Search results for "evolution [Galaxy]"
showing 10 items of 25 documents
Genetic Variability of Hepatitis C Virus before and after Combined Therapy of Interferon plus Ribavirin
2008
We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR binding domain and the V3 domain in the NS5A region. We used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation of therapy and after 6 or/and 12 months of treatment. A range of 25-100 clones per patient, genome region and time sample were sequenced. These were used to detect general patterns of adaptation, t…
Vecchi e nuovi problemi in tema di intervento dei creditori nell’esecuzione (note a margine di Cass. S.U. n. 61 del 7 gennaio 2014)
2015
Nel contributo in oggetto l'autore, muovendo dalla decisione delle Sezioni Unite della Cassazione n. 61 del 7 gennaio 2014, coglie l'occasione per riesaminare le vecchie e nuove problematiche sottese all’intervento dei creditori nel processo esecutivo. Il primo tema affrontato è quello della par condicio creditorum, che viene esaminata nella sua storia evolutiva dal Code Napoleon, al suo periodo di massima estensione, dato dal codice del 1940, fino al suo ridimensionamento a seguito delle riforme del 2005. Esamina quindi la possibilità del possibile superamento quoad effectum della distinzione tra intervento di creditori con titolo e senza titolo, alla luce delle evoluzioni della giurisprud…
Distinct Clones of Yersinia pestis Caused the Black Death
2010
From AD 1347 to AD 1353, the Black Death killed tens of millions of people in Europe, leaving misery and devastation in its wake, with successive epidemics ravaging the continent until the 18th century. The etiology of this disease has remained highly controversial, ranging from claims based on genetics and the historical descriptions of symptoms that it was caused by Yersinia pestis to conclusions that it must have been caused by other pathogens. It has also been disputed whether plague had the same etiology in northern and southern Europe. Here we identified DNA and protein signatures specific for Y. pestis in human skeletons from mass graves in northern, central and southern Europe that …
Improving High Frequency Transformers behavior for DC-DC Converter Used in Electric Vehicles
2018
The paper presents a design procedure for high frequency transformer windings adopted in the DC-DC converter used in electric vehicles. The output of the design procedure is the integration of a 3D printed plastic case in the transformer windings, with the aim to maximize the output power. The proposal design procedure is entirely based on a finite element analysis approach and on a differential evolution algorithm used for the solution of the optimization problem.
Adaptive discontinuous evolution Galerkin method for dry atmospheric flow
2014
We present a new adaptive genuinely multidimensional method within the framework of the discontinuous Galerkin method. The discontinuous evolution Galerkin (DEG) method couples a discontinuous Galerkin formulation with approximate evolution operators. The latter are constructed using the bicharacteristics of multidimensional hyperbolic systems, such that all of the infinitely many directions of wave propagation are considered explicitly. In order to take into account multiscale phenomena that typically appear in atmospheric flows nonlinear fluxes are split into a linear part governing the acoustic and gravitational waves and a nonlinear part that models advection. Time integration is realiz…
Robustez genética, epistasia y evolución de los virus de RNA
2005
Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe
2019
International audience; Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic mtDNA signature disappeared and was replaced by haplotypes associated with European wild boars. This turnover could be accounted for by substantial gene flow from local Euro-pean wild boars, although it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hyp…
L’innovazione tecnologica e il Faculty Development.
2023
La crisi pandemica ha accelerato la diffusione di ambienti di apprendimento caratterizzati dall'uso intensivo della tecnologia. Questa novità rappresenta un obiettivo trasversale della professionalizzazione del docente universitario, con una particolare declinazione sul versante pedagogico-didattico-valutativo quale questione strategica per lo sviluppo dell’alta formazione. Il contributo illustra i risultati di una ricerca condotta con 119 docenti universitari neoassunti e 20 Direttori di dipartimento. La finalità della ricerca è stata, da una parte, rilevare la percezione dei docenti neoassunti relativa alle proprie competenze didattiche, metacognitive e valutative, con riferimento alla di…
Evolución del genoma mitocondrial de especies del grupo obscura de Drosophila
1992
Evidence of Recombination in Intrapatient Populations of Hepatitis C Virus.
2008
Hepatitis C virus (HCV) is a major cause of liver disease worldwide and a potential cause of substantial morbidity and mortality in the future. HCV is characterized by a high level of genetic heterogeneity. Although homologous recombination has been demonstrated in many members of the family Flaviviridae, to which HCV belongs, there are only a few studies reporting recombination on natural populations of HCV, suggesting that these events are rare in vivo. Furthermore, these few studies have focused on recombination between different HCV genotypes/subtypes but there are no reports on the extent of intra-genotype or intra-subtype recombination between viral strains infecting the same patient.…